Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.32 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398531 | 0.84 | LMNA (0.36) | TLR7CDK1LMNAABCB11 | |
| SCHEMBL18398421 | 0.83 | JAK2 (0.35) | CDK1JAK2JAK3JAK1TYK2 | |
| SCHEMBL18398264 | 0.77 | JAK2 (0.39) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL18398235 | 0.77 | MAPT (0.43) | LMNA | |
| SCHEMBL18409422 | 0.76 | CDK1 (0.42) | TLR7CDK1 | |
| SCHEMBL18398296 | 0.76 | JAK2 (0.37) | TLR7JAK2JAK3JAK1TYK2 | |
| SCHEMBL18398397 | 0.70 | JAK2 (0.49) | JAK2JAK3JAK1TYK2LMNA | |
| SCHEMBL18409182 | 0.69 | CDK1 (0.42) | CDK1 | |
| SCHEMBL18398418 | 0.69 | MAP2K2 (0.38) | JAK2JAK3JAK1TYK2LMNA | |
| SCHEMBL18398511 | 0.68 | CYP1A2 (0.43) | JAK2JAK3JAK1TYK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |