Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424189 | 0.75 | HTR2A (0.31) | — | |
| SCHEMBL18399247 | 0.73 | DRD2 (0.36) | — | |
| SCHEMBL20424075 | 0.66 | MEN1 (0.41) | — | |
| SCHEMBL18398932 | 0.65 | SLC6A2 (0.43) | — | |
| SCHEMBL27656805 | 0.64 | MAOA (0.44) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL7297825 | 0.64 | MAOA (0.59) | MAOAMAOB | |
| SCHEMBL1636984 | 0.63 | MAOA (1.00) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL16461902 | 0.62 | MAOA (0.68) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL27394560 | 0.61 | MAOA (0.55) | MAOAMAOBCYP3A4CYP2D6HRH1 | |
| SCHEMBL28059116 | 0.60 | MAOB (0.46) | MAOAMAOBCYP3A4CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |