Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399363 | 0.91 | GRIN2D (0.49) | HDAC1HDAC6BCHEGRIN2DGRIN3B | |
| SCHEMBL18399355 | 0.86 | HDAC1 (0.46) | HDAC1HDAC6PTGER4BCHEBAZ2B | |
| SCHEMBL3235723 | 0.85 | BCHE (0.48) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL3238824 | 0.85 | MAOA (0.46) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL18399356 | 0.82 | HDAC1 (0.43) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL3241053 | 0.80 | HDAC1 (0.46) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL3234803 | 0.79 | BCHE (0.49) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL13654458 | 0.79 | BCHE (0.47) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL3236149 | 0.79 | HDAC1 (0.49) | HDAC1HDAC6BCHEBAZ2BGRIN2D | |
| SCHEMBL3237881 | 0.78 | GRIN2D (0.53) | HDAC1HDAC6BCHEGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550782-B2 | Compounds and methods for treating diabetes | MEDIVATION TECHNOLOGIES, INC. (US) | 2017-01-24 | — | — | US | disclosed |