Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 20/20 | 0.53 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16569368 | 0.91 | RORC (0.61) | RORCPPARG | |
| SCHEMBL16569322 | 0.82 | RORC (0.67) | RORCPPARG | |
| SCHEMBL18399874 | 0.81 | RORC (0.44) | RORC | |
| SCHEMBL4321632 | 0.80 | CNR1 (0.59) | RORCPPARG | |
| SCHEMBL19726644 | 0.77 | RORC (0.42) | RORC | |
| SCHEMBL18086803 | 0.77 | RORC (0.86) | RORCPPARG | |
| SCHEMBL18031312 | 0.74 | KMT2A (0.44) | — | |
| SCHEMBL31325969 | 0.74 | MAP2K3 (0.43) | RORC | |
| SCHEMBL18086811 | 0.73 | RORC (0.67) | RORC | |
| SCHEMBL26684420 | 0.71 | MAP2K3 (0.58) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550771-B2 | Keto-imidazopyridine derivatives as RORc modulators | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |