Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657230 | 0.84 | NR1H4 (0.41) | NR1H4 | |
| SCHEMBL1843649 | 0.82 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1841904 | 0.82 | NR1H4 (0.37) | NR1H4 | |
| SCHEMBL3654638 | 0.79 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL3801443 | 0.78 | NR1H4 (0.56) | NR1H4 | |
| SCHEMBL1841564 | 0.78 | NR1H4 (0.40) | NR1H4 | |
| SCHEMBL1836831 | 0.76 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL3657964 | 0.76 | NR1H4 (0.44) | NR1H4 | |
| SCHEMBL1840602 | 0.75 | NR1H4 (0.36) | NR1H4 | |
| SCHEMBL1839157 | 0.75 | NR1H4 (0.37) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-B1 | NEW BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2013-03-27 | — | — | EP | disclosed |
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |