Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 10/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841802 | 0.86 | NR1H4 (0.33) | — | |
| SCHEMBL1843296 | 0.86 | — | — | |
| SCHEMBL1839494 | 0.84 | NR1H4 (0.42) | CYP2D6 | |
| SCHEMBL1839238 | 0.84 | NR1H4 (0.42) | CYP2D6 | |
| SCHEMBL1838802 | 0.83 | NR1H4 (0.33) | — | |
| SCHEMBL3236034 | 0.83 | DRD4 (0.31) | — | |
| SCHEMBL1840576 | 0.82 | NR1H4 (0.32) | — | |
| SCHEMBL1842326 | 0.82 | PTGDR2 (0.34) | — | |
| SCHEMBL1841658 | 0.82 | GABRA5 (0.38) | ALOX5APFEN1 | |
| SCHEMBL1842541 | 0.82 | GABRA5 (0.38) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |