Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | EGFR | P00533 | 10/20 | 0.46 |
| ▸ | CSK | P41240 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 3/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | ARAF | P10398 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17324327 | 0.92 | ABL1 (0.52) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL17313596 | 0.92 | ABL1 (0.52) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403089 | 0.90 | MAPK14 (0.52) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403164 | 0.89 | MAP3K20 (0.54) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403165 | 0.86 | MAPK14 (0.47) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403131 | 0.86 | MAPK14 (0.50) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403051 | 0.85 | CSK (0.49) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL18403163 | 0.84 | CSK (0.49) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL17324210 | 0.83 | CSK (0.59) | BRAFEGFRCSKMAPK14ABL1 | |
| SCHEMBL17313594 | 0.83 | CSK (0.59) | BRAFEGFRCSKMAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550772-B2 | Azaindole derivatives as multi kinase inhibitors | ORIBASE PHARMA (FR) | 2017-01-24 | — | — | US | disclosed |