Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | CSK | P41240 | 4/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 11/20 | 0.47 |
| ▸ | BCR | P11274 | 6/20 | 0.47 |
| ▸ | LYN | P07948 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | FRK | P42685 | 2/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.47 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18403163 | 0.94 | CSK (0.49) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL18403165 | 0.93 | MAPK14 (0.47) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL17324210 | 0.93 | CSK (0.59) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL17313594 | 0.93 | CSK (0.59) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL18403164 | 0.91 | MAP3K20 (0.54) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL18403131 | 0.90 | MAPK14 (0.50) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL18403161 | 0.90 | BRAF (0.46) | MAPK14CSKMAP3K20EPHA2ABL1 | |
| SCHEMBL15860000 | 0.90 | BRAF (0.58) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL17324205 | 0.90 | MAP3K20 (0.54) | MAPK14CSKMAP3K20MAP4K2EPHA2 | |
| SCHEMBL18403051 | 0.89 | CSK (0.49) | MAPK14CSKMAP3K20MAP4K2EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550772-B2 | Azaindole derivatives as multi kinase inhibitors | ORIBASE PHARMA (FR) | 2017-01-24 | — | — | US | disclosed |