Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | CSK | P41240 | 4/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 12/20 | 0.45 |
| ▸ | BCR | P11274 | 6/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 4/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.42 |
| ▸ | ABL2 | P42684 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18403089 | 0.93 | MAPK14 (0.52) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL15860032 | 0.93 | CSK (0.54) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL17313585 | 0.93 | CSK (0.54) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL18403164 | 0.90 | MAP3K20 (0.54) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL15860030 | 0.90 | ABL1 (0.56) | MAPK14MAP3K20ABL1BCRRET | |
| SCHEMBL18403163 | 0.86 | CSK (0.49) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL18403131 | 0.86 | MAPK14 (0.50) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL17313594 | 0.86 | CSK (0.59) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL17324210 | 0.86 | CSK (0.59) | MAPK14CSKMAP3K20ABL1BCR | |
| SCHEMBL18403161 | 0.86 | BRAF (0.46) | MAPK14CSKMAP3K20ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550772-B2 | Azaindole derivatives as multi kinase inhibitors | ORIBASE PHARMA (FR) | 2017-01-24 | — | — | US | disclosed |