Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737903 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2KDM4EMAP3K12PDE2APSMB8 | |
| SCHEMBL17407482 | 0.83 | PSMB8 (0.34) | KDM4EALDH1A1MAP3K12PSMB8PSMB9 | |
| SCHEMBL18685612 | 0.80 | MAP3K12 (0.53) | KDM4EALDH1A1MAP3K12PDE2AEPHX2 | |
| SCHEMBL23132293 | 0.76 | PSMB8 (0.41) | SMN1; SMN2KDM4EALDH1A1PDE2APSMB8 | |
| SCHEMBL18403363 | 0.76 | MAP3K12 (0.45) | SMN1; SMN2KDM4EALDH1A1MAP3K12PDE2A | |
| SCHEMBL17454466 | 0.73 | PSMB8 (0.45) | ALDH1A1MAP3K12PDE2APSMB8PSMB9 | |
| SCHEMBL24746024 | 0.73 | PDE2A (0.44) | PDE2A | |
| SCHEMBL18403301 | 0.73 | PLAT (0.43) | — | |
| SCHEMBL18403206 | 0.73 | CHRNB2 (0.37) | SMN1; SMN2 | |
| SCHEMBL9620236 | 0.71 | SMN1; SMN2 (0.34) | SMN1; SMN2KDM4EPDE2APSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550777-B2 | 3-substituted pyrazoles and use as DLK inhibitors | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |