Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 7/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23132293 | 0.90 | PSMB8 (0.41) | SMN1; SMN2PDE2ATDP2PSMB8PSMB9 | |
| SCHEMBL14451899 | 0.88 | QDPR (0.39) | PDE2AMAP3K12EPHX2 | |
| SCHEMBL18403301 | 0.87 | PLAT (0.43) | PLAT | |
| SCHEMBL24746024 | 0.87 | PDE2A (0.44) | PDE2ATDP2 | |
| SCHEMBL18403238 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2PDE2ATSHRPSMB8PSMB9 | |
| SCHEMBL18403206 | 0.82 | CHRNB2 (0.37) | SMN1; SMN2 | |
| SCHEMBL18685612 | 0.80 | MAP3K12 (0.53) | PDE2AKDM4EMAP3K12EPHX2 | |
| SCHEMBL18403286 | 0.79 | MAP3K12 (0.48) | MAP3K12 | |
| SCHEMBL11793035 | 0.78 | PLAT (0.37) | SMN1; SMN2PSMB8PSMB9MAP3K12PLAT | |
| SCHEMBL2795050 | 0.77 | RET (0.33) | PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059186-A1 | N-((ISOQUINOLIN-6-YL)METHYL)-1H-PYRAZOLE-4-CARBOXAMID DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS FOR THE TREATMENT OF HEREDITARY ANGIOEDEMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-03-21 | — | — | WO | disclosed |
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
| US-11352356-B2 | Inhibitors of plasma kallikrein and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-06-07 | — | — | US | disclosed |
| EP-3765459-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | Shire Human Genetic Therapies, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| US-20200390100-A1 | SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES | BAYER AG (DE) | 2020-12-17 | — | — | US | disclosed |
| US-20200317667-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. | 2020-10-08 | — | — | US | disclosed |
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2018114596-A1 | SUBSTITUTED HETEROARYL PYRROLONES AND SALTS THEREOF AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-06-28 | — | — | WO | disclosed |
| US-8247401-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2012-08-21 | — | — | US | disclosed |
| US-8202875-B2 | Selective insecticides based on substituted cyclic ketoenols and safeners | BAYER CROPSCIENCE AG (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20080293676-A1 | Insecticidal Agents Based on Selected Insecticides and Safeners | BAYER CROPSCIENCE AG (DE) | 2008-11-27 | — | — | US | disclosed |
| US-20080261810-A1 | Insecticides Based on Neonicotinoids and Safeners | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2008-10-23 | — | — | US | disclosed |
| US-7432225-B2 | Selective herbicides based on substituted cyclic keto-enols and safeners | BAYER CROPSCIENCE AG (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1974607-A2 | Selective insecticides based on anthranilic acid diamides and safeners | Bayer CropScience AG (DE) | 2008-10-01 | — | — | EP | disclosed |
| US-20080220973-A1 | 2-Alkoxy-6-Alkyl-Phenyl-Substituted Spirocyclic Tetramic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221167-A1 | for controlling insects and/or arachnids | BAYER CROPSCIENCE AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-7420062-B2 | Hetaryl-substituted pyrazolidindione derivatives with pesticidal characteristics | BAYER CROPSCIENCE, AG (DE) | 2008-09-02 | — | — | US | disclosed |
| US-20080200499-A1 | Selective Insecticides and/or Acaricides Based on Substituted Cyclic Dicarbonyl Compounds and Safeners | BAYER CROPSCIENCE AG (DE) | 2008-08-21 | — | — | US | disclosed |
| US-20080188371-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2008-08-07 | — | — | US | disclosed |
| US-20080026943-A1 | Phenyl-Substituted [1,2]-Oxazine-3,5-Dione and Dihydropyrone Derivatives | BAYER CROPSCIENCE AG (DE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352356-B2 | Inhibitors of plasma kallikrein and uses thereof | KLKB1, KLK1, KLK5 | SMN1; SMN2 4772/4885PDE2A 1216/4885TDP2 3587/4885 |
| US-20200390100-A1 | SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES | DDT, NOTUM, AGPS | SMN1; SMN2 4626/4885PDE2A 938/4885TDP2 3241/4885 |
| US-20080220973-A1 | 2-Alkoxy-6-Alkyl-Phenyl-Substituted Spirocyclic Tetramic Acid Derivatives | DDT, PAOX, PTPRG | SMN1; SMN2 4498/4885PDE2A 1904/4885TDP2 1081/4885 |
| US-20080261810-A1 | Insecticides Based on Neonicotinoids and Safeners | CYP4X1, PRDX4, PRDX1 | SMN1; SMN2 363/4885PDE2A 2987/4885TDP2 3015/4885 |
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | SMN1; SMN2 1956/4885PDE2A 130/4885TDP2 3884/4885 |
| US-20080188371-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | DDT, CYP4X1, HPD | SMN1; SMN2 4748/4885PDE2A 951/4885TDP2 977/4885 |
| US-20200317667-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | KLKB1, KLK1, KLK5 | SMN1; SMN2 4772/4885PDE2A 1216/4885TDP2 3587/4885 |
| US-20080200499-A1 | Selective Insecticides and/or Acaricides Based on Substituted Cyclic Dicarbonyl Compounds and Safeners | DDT, AADAC, ACMSD | SMN1; SMN2 2773/4885PDE2A 1817/4885TDP2 4042/4885 |
| US-20080026943-A1 | Phenyl-Substituted [1,2]-Oxazine-3,5-Dione and Dihydropyrone Derivatives | DDT, CYP1A1, CYP1B1 | SMN1; SMN2 4047/4885PDE2A 969/4885TDP2 1064/4885 |
| US-20080221167-A1 | for controlling insects and/or arachnids | CRYAB, DDC, DDT | SMN1; SMN2 3827/4885PDE2A 2519/4885TDP2 4132/4885 |
| US-20080293676-A1 | Insecticidal Agents Based on Selected Insecticides and Safeners | ACHE, NCS1, HCN1 | SMN1; SMN2 3505/4885PDE2A 714/4885TDP2 4156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.