Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 11/20 | 0.46 |
| ▸ | GUCY1A2 | P33402 | 11/20 | 0.46 |
| ▸ | GUCY1A1 | Q02108 | 11/20 | 0.46 |
| ▸ | GUCY1B1 | Q02153 | 11/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 7/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075373 | 0.81 | GUCY1B2 (0.53) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18899302 | 0.79 | GUCY1B2 (0.37) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL15075434 | 0.79 | GUCY1B2 (0.51) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL15075440 | 0.79 | GUCY1B2 (0.51) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL3437391 | 0.76 | GUCY1B2 (0.80) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18899080 | 0.74 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL14843520 | 0.71 | BUB1 (0.68) | BUB1 | |
| SCHEMBL16324219 | 0.71 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL18899190 | 0.71 | GUCY1B2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL15075385 | 0.70 | BUB1 (0.50) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588465-B1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS INC (US) | 2017-01-25 | — | — | EP | disclosed |