Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121590 | 0.83 | ADORA3 (0.32) | — | |
| SCHEMBL13811523 | 0.81 | — | — | |
| SCHEMBL2953678 | 0.78 | ADORA3 (0.38) | DHFR | |
| SCHEMBL10121645 | 0.76 | ADORA2A (0.31) | — | |
| SCHEMBL1146282 | 0.76 | PDE4B (0.34) | — | |
| SCHEMBL12857099 | 0.76 | CYP1A2 (0.38) | — | |
| SCHEMBL887193 | 0.76 | MAP4K4 (0.39) | PIK3CG | |
| SCHEMBL2542341 | 0.74 | TLR7 (0.41) | — | |
| SCHEMBL14224934 | 0.73 | ADORA2A (0.40) | — | |
| SCHEMBL13849616 | 0.73 | KCNH3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324026-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | Smithkline Beecham Corporation (US) | 2011-05-25 | — | — | EP | disclosed |
| EP-2320905-A1 | NOVEL ADENINE DERIVATIVES | Smithkline Beecham Corporation (US) | 2011-05-18 | — | — | EP | disclosed |