Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409285 | 0.89 | TYK2 (0.62) | JAK1JAK2TYK2JAK3ABL1 | |
| SCHEMBL18409114 | 0.85 | TYK2 (0.46) | JAK1JAK2TYK2JAK3PIK3C3 | |
| SCHEMBL18409324 | 0.81 | JAK2 (0.59) | JAK1JAK2TYK2JAK3NPC1 | |
| SCHEMBL18409117 | 0.81 | TYK2 (0.55) | JAK1JAK2TYK2JAK3ABL1 | |
| SCHEMBL18409202 | 0.81 | TYK2 (0.53) | JAK1JAK2TYK2JAK3ABL1 | |
| SCHEMBL18409322 | 0.79 | TYK2 (0.53) | JAK1JAK2TYK2JAK3ABL1 | |
| SCHEMBL18398418 | 0.79 | MAP2K2 (0.38) | JAK1JAK2TYK2JAK3MAPK14 | |
| SCHEMBL18398421 | 0.78 | JAK2 (0.35) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18409103 | 0.78 | JAK2 (0.43) | JAK1JAK2TYK2JAK3PIK3C3 | |
| SCHEMBL18409286 | 0.76 | JAK2 (0.47) | JAK1JAK2TYK2JAK3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |