Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | CHUK | O15111 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398596 | 0.91 | JAK2 (0.43) | JAK2JAK1JAK3TYK2TRPV1 | |
| SCHEMBL18398598 | 0.85 | TYK2 (0.47) | JAK2JAK1JAK3TYK2TRPV1 | |
| SCHEMBL18409202 | 0.82 | TYK2 (0.53) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18409114 | 0.81 | TYK2 (0.46) | JAK2JAK1JAK3TYK2GSK3B | |
| SCHEMBL18409108 | 0.78 | JAK1 (0.47) | JAK2JAK1JAK3TYK2GSK3B | |
| SCHEMBL18409111 | 0.78 | JAK2 (0.52) | JAK2JAK1JAK3TYK2TRPV1 | |
| SCHEMBL18409102 | 0.77 | LMNA (0.33) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18398409 | 0.77 | JAK1 (0.34) | JAK2JAK1JAK3TYK2TRPV1 | |
| SCHEMBL18398581 | 0.76 | JAK2 (0.53) | JAK2JAK1JAK3TYK2GSK3B | |
| SCHEMBL18409287 | 0.76 | JAK2 (0.47) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |