Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398215 | 0.80 | DCTPP1 (0.42) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL4930882 | 0.78 | NPC1 (0.65) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL28149996 | 0.77 | KMT2A (0.56) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL563184 | 0.76 | EGFR (0.53) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL4897695 | 0.74 | CA1 (0.57) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL25379641 | 0.74 | MAPT (0.64) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL10506512 | 0.73 | EGFR (0.57) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL1743488 | 0.72 | EGFR (0.55) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL30669799 | 0.72 | NPC1 (0.54) | EGFRHTTGAAMAPTNPC1 | |
| SCHEMBL24615283 | 0.72 | NPC1 (0.54) | EGFRHTTGAAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |