Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29072235 | 0.87 | ATM (0.50) | MAPTNPSR1EGFRBLMLMNA | |
| SCHEMBL23589666 | 0.85 | MAPT (0.48) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL29072197 | 0.82 | APP (0.50) | MAPTNPSR1EGFRALDH1A1 | |
| SCHEMBL563184 | 0.81 | EGFR (0.53) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL10506512 | 0.78 | EGFR (0.57) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL562257 | 0.77 | MAPT (0.49) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL563543 | 0.77 | MAPT (0.48) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL18409145 | 0.74 | EGFR (0.55) | MAPTNPSR1EGFRMAPK1BLM | |
| SCHEMBL29090412 | 0.74 | ATM (0.51) | MAPTNPSR1EGFRBLMHPGD | |
| SCHEMBL30547170 | 0.74 | ATM (0.51) | MAPTNPSR1EGFRBLMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023165570-A1 | CYCLOALKYL OR HETEROCYCLYL SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND USE THEREOF | 深圳市塔吉瑞生物医药有限公司 | 2023-09-07 | — | — | WO | disclosed |
| CN-116693458-A | Cycloalkyl or heterocyclyl substituted heteroaryl compounds, compositions and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2023-09-05 | — | — | CN | disclosed |