Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.47 |
| ▸ | JAK1 | P23458 | 11/20 | 0.47 |
| ▸ | TYK2 | P29597 | 11/20 | 0.47 |
| ▸ | JAK3 | P52333 | 11/20 | 0.47 |
| ▸ | SIK1 | P57059 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18408890 | 0.89 | TYK2 (0.43) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18398581 | 0.86 | JAK2 (0.53) | JAK2JAK1TYK2JAK3TBK1 | |
| SCHEMBL18409202 | 0.85 | TYK2 (0.53) | JAK2JAK1TYK2JAK3TBK1 | |
| SCHEMBL18398479 | 0.83 | JAK2 (0.52) | JAK2JAK1TYK2JAK3SIK1 | |
| SCHEMBL18398314 | 0.82 | JAK2 (0.41) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18409114 | 0.81 | TYK2 (0.46) | JAK2JAK1TYK2JAK3ABL1 | |
| SCHEMBL18409413 | 0.80 | JAK2 (0.54) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398577 | 0.80 | JAK2 (0.48) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18409285 | 0.80 | TYK2 (0.62) | JAK2JAK1TYK2JAK3TBK1 | |
| SCHEMBL18398248 | 0.79 | JAK2 (0.41) | JAK2JAK1TYK2JAK3SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |