Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655355 | 0.88 | GPR52 (0.41) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL18415686 | 0.85 | FGFR4 (0.44) | GPR52PRMT5WDR77 | |
| SCHEMBL19365868 | 0.85 | GPR52 (0.38) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL17655442 | 0.85 | GPR52 (0.36) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL12959030 | 0.85 | FGFR4 (0.45) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL12805953 | 0.85 | FGFR4 (0.45) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL12805950 | 0.85 | FGFR4 (0.45) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL17655393 | 0.85 | GPR52 (0.37) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL19706090 | 0.84 | GPR52 (0.35) | RAF1GPR52TRPV3CA2CA9 | |
| SCHEMBL12654065 | 0.82 | TRPM8 (0.42) | CA2CA9KDM1APHGDHCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |