Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829997 | 1.00 | TLR8 (0.47) | TLR8TLR7PDE4APDE4BPDE4C | |
| SCHEMBL17830001 | 0.93 | TLR8 (0.44) | TLR8TLR7PDE4APDE4BPDE4C | |
| SCHEMBL17829980 | 0.87 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL17829986 | 0.87 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL17830000 | 0.87 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL17829978 | 0.79 | TLR8 (0.60) | TLR8TLR7CXCR2KCNH2 | |
| SCHEMBL17829988 | 0.79 | TLR8 (0.60) | TLR8TLR7CXCR2KCNH2 | |
| SCHEMBL17829982 | 0.79 | KCNH2 (0.65) | TLR8TLR7KCNH2 | |
| SCHEMBL17829998 | 0.78 | TLR8 (0.42) | TLR8TLR7KCNH2 | |
| SCHEMBL17830002 | 0.77 | TLR8 (0.42) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556199-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-01-31 | — | — | US | disclosed |