Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | PRKCI | P41743 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16441144 | 0.88 | TLR8 (0.56) | TLR8TLR7KCNH2 | |
| SCHEMBL22448326 | 0.77 | PRKCI (0.49) | TLR8TLR7KCNH2CRHR1PRKCI | |
| SCHEMBL17829997 | 0.77 | TLR8 (0.47) | TLR8TLR7KCNH2 | |
| SCHEMBL18415705 | 0.77 | TLR8 (0.47) | TLR8TLR7KCNH2 | |
| SCHEMBL16441143 | 0.75 | TLR8 (0.60) | TLR8TLR7KCNH2 | |
| SCHEMBL17830003 | 0.75 | TLR8 (0.60) | TLR8TLR7KCNH2 | |
| SCHEMBL16441145 | 0.75 | TLR8 (0.60) | TLR8TLR7KCNH2 | |
| SCHEMBL22448325 | 0.73 | TLR8 (0.42) | TLR8TLR7KCNH2PRKCI | |
| SCHEMBL17829998 | 0.72 | TLR8 (0.42) | TLR8TLR7KCNH2CRHR1 | |
| SCHEMBL17830001 | 0.69 | TLR8 (0.44) | TLR8TLR7KCNH2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556199-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-01-31 | — | — | US | disclosed |
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885KCNH2 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.