Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 5/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12989329 | 0.84 | KMT2A (0.64) | MDM2RAB9AKDM4EKEAP1NFE2L2 | |
| SCHEMBL8338635 | 0.82 | EPHX1 (0.63) | RAB9AKDM4ETAAR1HTTKMT2A | |
| SCHEMBL11310806 | 0.81 | NAMPT (0.65) | MDM2RAB9AKDM4EKEAP1NFE2L2 | |
| SCHEMBL2958982 | 0.81 | MDM2 (0.62) | MDM2RAB9AKDM4EKEAP1NFE2L2 | |
| SCHEMBL15196112 | 0.80 | MDM2 (0.67) | MDM2RAB9ATAAR1HTTKMT2A | |
| Hydrochloric Acid SCHEMBL11310061 | 0.80 | NAMPT (0.64) | MDM2RAB9AKDM4EKEAP1NFE2L2 | |
| SCHEMBL9868290 | 0.79 | BCHE (0.62) | MDM2RAB9AKDM4EKEAP1NFE2L2 | |
| SCHEMBL7789976 | 0.77 | MDM2 (0.75) | MDM2RAB9AKDM4ETAAR1KMT2A | |
| SCHEMBL10020286 | 0.77 | MDM2 (1.00) | MDM2RAB9AKDM4ETAAR1HTT | |
| SCHEMBL17030472 | 0.76 | KEAP1 (0.54) | MDM2RAB9AKDM4EKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |