Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGAV | P06756 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20335072 | 0.84 | ITGB3 (0.63) | HTTKDM4ES1PR1MEN1KMT2A | |
| SCHEMBL12989329 | 0.81 | KMT2A (0.64) | MDM2TAAR1HTTROCK2ROCK1 | |
| SCHEMBL2958982 | 0.81 | MDM2 (0.62) | MDM2TAAR1HTTROCK2ROCK1 | |
| SCHEMBL19428148 | 0.79 | FOLH1 (0.60) | S1PR1MEN1KMT2AITGB3ITGAV | |
| SCHEMBL27183437 | 0.79 | S1PR1 (0.57) | S1PR1NAMPTMEN1KMT2AITGB3 | |
| SCHEMBL18436112 | 0.79 | MDM2 (0.60) | BCHEMDM2TAAR1HTTROCK2 | |
| SCHEMBL9867948 | 0.79 | ALDH1A1 (0.61) | MDM2TAAR1ROCK2ROCK1KDM4E | |
| SCHEMBL3197308 | 0.78 | BCHE (0.59) | BCHEMDM2TAAR1HTTKDM4E | |
| SCHEMBL11310806 | 0.78 | NAMPT (0.65) | MDM2HTTKDM4EKEAP1NFE2L2 | |
| SCHEMBL27322900 | 0.78 | HTT (0.58) | HTTROCK2ROCK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997667-A | Pyridinyl compounds of N-carbamoyl-N-thiocarbamoyl- or N-amidino-glycine or beta-alanine useful as sweetening agents | UNIVERSITE CLAUDE BERNARD (FR) | 1991-03-05 | — | — | US | claimed |
| US-4997667-A | Pyridinyl compounds of N-carbamoyl-N-thiocarbamoyl- or N-amidino-glycine or beta-alanine useful as sweetening agents | UNIVERSITE CLAUDE BERNARD (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0321369-A1 | Heterocyclic sweeteners derived from N-carbamoyl-, N-thiocarbamoyl or N-amidino-glycine or beta-alanine | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 1989-06-21 | — | — | EP | disclosed |