Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731838 | 0.90 | MAPT (0.41) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL11794003 | 0.81 | NR4A1 (0.41) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL11172746 | 0.79 | MEN1 (0.43) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL1800738 | 0.79 | MEN1 (0.44) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL11168145 | 0.76 | GAA (0.44) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL8606919 | 0.76 | SLC6A2 (0.50) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL11173870 | 0.74 | ALDH1A1 (0.48) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL9336944 | 0.73 | MEN1 (0.40) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL15165910 | 0.73 | MAPT (0.44) | MAPTGAAMEN1KMT2ARAB9A | |
| SCHEMBL24386214 | 0.72 | FFAR2 (0.39) | MAPTGAAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |