Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21737323 | 0.68 | — | — | |
| SCHEMBL28865194 | 0.66 | KDM4E (0.49) | MAPTSMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL68340 | 0.66 | PKM (0.60) | SMN1; SMN2LMNAKMT2APKMHSD17B10 | |
| SCHEMBL25664507 | 0.66 | GAA (0.57) | SMN1; SMN2LMNAKDM4ECA12CA1 | |
| SCHEMBL703931 | 0.66 | MAPT (0.72) | MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL6367851 | 0.66 | MAPT (0.51) | MAPTSMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL16731569 | 0.66 | KMT2A (0.49) | MAPTSMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL68851 | 0.65 | CYP4Z1 (0.62) | MAPTSMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL137425 | 0.64 | HSP90AB1 (0.51) | MAPTSMN1; SMN2LMNAKDM4ECA12 | |
| SCHEMBL24690441 | 0.64 | MAPT (0.47) | MAPTSMN1; SMN2LMNAKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |