Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18435947 | 0.83 | NPC1 (0.47) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL22907273 | 0.81 | SLC6A4 (0.43) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL18375724 | 0.81 | SLC6A4 (0.45) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL13324495 | 0.78 | SLC6A4 (0.43) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL16954821 | 0.78 | SLC6A4 (0.43) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL2918697 | 0.78 | FFAR4 (0.44) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL2708451 | 0.75 | SLC6A4 (0.51) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL30301996 | 0.75 | SLC6A4 (0.51) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL20601709 | 0.74 | SLC6A4 (0.45) | FFAR4SLC6A4SLC6A3NPC1CASP3 | |
| SCHEMBL8890759 | 0.73 | PLA2G2A (0.43) | FFAR4SLC6A4SLC6A3PLA2G2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822953-B9 | MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | PFIZER (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-2822953-B1 | MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | PFIZER (US) | 2017-02-01 | — | — | EP | disclosed |