Sugi Predict

Sugi Predict / Compounds / SCHEMBL20601709

SCHEMBL20601709

SCHEMBL20601709

COC(=O)c1cc(F)ccc1C(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A4 P31645 1/20 0.45
▸ SLC6A3 Q01959 1/20 0.45
▸ FFAR4 Q5NUL3 1/20 0.43
▸ PLA2G2A P14555 3/20 0.42
▸ CYP1A2 P05177 2/20 0.41
▸ TSHR P16473 2/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ CASP3 P42574 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ SENP8 Q96LD8 1/20 0.41
▸ SENP7 Q9BQF6 1/20 0.41
▸ SENP6 Q9GZR1 1/20 0.41
▸ PDK2 Q15119 2/20 0.40
▸ CES2 O00748 2/20 0.40
▸ CES1 P23141 2/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ CA12 O43570 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14084345 0.86 SLC6A4 (0.49) SLC6A4SLC6A3PLA2G2ACYP1A2TSHR
SCHEMBL10154075 0.83 SLC6A4 (0.43) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL2919219 0.83 SLC6A4 (0.43) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL26620169 0.81 SLC6A4 (0.41) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL30296763 0.81 SLC6A4 (0.41) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL17310005 0.80 CES2 (0.44) FFAR4TSHRSMN1; SMN2CES2CES1
SCHEMBL30301996 0.80 SLC6A4 (0.51) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL2708451 0.80 SLC6A4 (0.51) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2
SCHEMBL9951319 0.79 LOXL2 (0.51) TSHRSMN1; SMN2PDK2KDM4ECA12
SCHEMBL27268096 0.79 SLC6A4 (0.39) SLC6A4SLC6A3FFAR4PLA2G2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570638-B2 Fused imidazole derivatives as AHR antagonists SAIL BIOMEDICINES, INC. (US) 2026-03-10 — — US disclosed
CN-120025312-A Benzazepine derivatives 大塚制药株式会社 2025-05-23 — — CN disclosed
US-20250051310-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-02-13 — — US disclosed
EP-4056557-B1 BENZAZEPINE DERIVATIVES USEFUL AS MEDICAMENTS OTSUKA PHARMA CO LTD (JP) 2023-11-22 — — EP disclosed
US-20230331705-A1 Fused Imidazole Derivatives as AHR Antagonists SENDA BIOSCIENCES, INC. 2023-10-19 — — US disclosed
US-20230331705-A1 Fused Imidazole Derivatives as AHR Antagonists SENDA BIOSCIENCES, INC. 2023-10-19 — — US disclosed
US-20230265073-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-08-24 — — US disclosed
US-20230265073-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-08-24 — — US disclosed
US-20230265073-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-08-24 — — US disclosed
US-11673878-B2 Benzazepine derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-06-13 — — US disclosed
WO-2021236717-A1 FUSED IMIDAZOLE DERIVATIVES AS AHR ANTAGONISTS SENDA BIOSCIENCES, INC. (US) 2021-11-25 — — WO disclosed
US-20210078976-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-03-18 — — US disclosed
US-20210078976-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-03-18 — — US disclosed
US-10889570-B2 Benzazepine derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-01-12 — — US disclosed
US-10889570-B2 Benzazepine derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-01-12 — — US disclosed
EP-3645513-A1 BENZAZEPINE DERIVATIVES Otsuka Pharmaceutical Co., Ltd. (JP) 2020-05-06 — — EP disclosed
CN-110891939-A Benzazepine derivatives 大塚制药株式会社 2020-03-17 — — CN disclosed
WO-2020021024-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF THE ARYL HYDROCARBON RECEPTOR (AHR) PHENEX PHARMACEUTICALS AG (DE) 2020-01-30 — — WO disclosed
WO-2020021024-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF THE ARYL HYDROCARBON RECEPTOR (AHR) PHENEX PHARMACEUTICALS AG (DE) 2020-01-30 — — WO disclosed
WO-2019004421-A1 BENZAZEPINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2019-01-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210078976-A1 BENZAZEPINE DERIVATIVES AVPR2, AVPR1A, AVPR1B SLC6A4 290/4885SLC6A3 230/4885FFAR4 1305/4885
US-20230265073-A1 BENZAZEPINE DERIVATIVES AVPR2, AVPR1A, AVPR1B SLC6A4 290/4885SLC6A3 230/4885FFAR4 1305/4885
US-11673878-B2 Benzazepine derivatives AVPR2, AVPR1A, AVPR1B SLC6A4 290/4885SLC6A3 230/4885FFAR4 1305/4885
US-20250051310-A1 BENZAZEPINE DERIVATIVES AVPR2, AVPR1A, AVPR1B SLC6A4 344/4885SLC6A3 277/4885FFAR4 1416/4885
US-10889570-B2 Benzazepine derivatives AVPR2, AVPR1A, AVPR1B SLC6A4 290/4885SLC6A3 230/4885FFAR4 1305/4885
US-20230331705-A1 Fused Imidazole Derivatives as AHR Antagonists AHR, ARNT, AIPL1 SLC6A4 3873/4885SLC6A3 4028/4885FFAR4 560/4885
US-12570638-B2 Fused imidazole derivatives as AHR antagonists AHR, ARNT, AIPL1 SLC6A4 2223/4885SLC6A3 2373/4885FFAR4 1440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.