Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073157 | 0.82 | AR (0.46) | L3MBTL1PTGES2NFE2L2MAPTSMN1; SMN2 | |
| SCHEMBL1073158 | 0.82 | AR (0.46) | L3MBTL1PTGES2NFE2L2MAPTSMN1; SMN2 | |
| SCHEMBL3717231 | 0.82 | AR (0.46) | L3MBTL1PTGES2NFE2L2MAPTSMN1; SMN2 | |
| SCHEMBL3669785 | 0.77 | NFE2L2 (0.45) | NFE2L2MAPTSMN1; SMN2GAALMNA | |
| SCHEMBL21110871 | 0.77 | NFE2L2 (0.45) | NFE2L2MAPTSMN1; SMN2GAALMNA | |
| SCHEMBL5426283 | 0.77 | PTGES2 (0.42) | L3MBTL1PTGES2POLBCA12CA9 | |
| SCHEMBL5426281 | 0.77 | PTGES2 (0.42) | L3MBTL1PTGES2POLBCA12CA9 | |
| SCHEMBL18145871 | 0.77 | PTGES2 (0.42) | L3MBTL1PTGES2POLBCA12CA9 | |
| SCHEMBL18145870 | 0.77 | PTGES2 (0.42) | L3MBTL1PTGES2POLBCA12CA9 | |
| SCHEMBL15678969 | 0.76 | POLB (0.45) | L3MBTL1PTGES2POLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331889-A1 | CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA | Bristol-Myers Squibb Company (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017023902-A1 | CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-02-09 | — | — | WO | disclosed |