SCHEMBL184465

SCHEMBL184465

COc1ccccc1CP(CCP(Cc1ccccc1OC)c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.46
TAAR1 Q96RJ0 1/20 0.46
CHRM2 P08172 2/20 0.44
CHRM1 P11229 1/20 0.44
HTT P42858 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
ALDH1A1 P00352 1/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
ATM Q13315 1/20 0.42
ABCB1 P08183 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
CA4 P22748 1/20 0.41
CA7 P43166 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9405346 0.93 IDO1 (0.48) IDO1TAAR1CHRM2CHRM1HTT
SCHEMBL10382784 0.90 HTT (0.49) IDO1TAAR1CHRM2CHRM1HTT
SCHEMBL10383681 0.88 LMNA (0.45) IDO1TAAR1CHRM2CHRM1L3MBTL1
SCHEMBL8854193 0.88 IDO1 (0.44) IDO1TAAR1CHRM2CHRM1HTT
SCHEMBL10382900 0.87 MEN1 (0.45) IDO1TAAR1CHRM2CHRM1ALDH1A1
SCHEMBL10382793 0.87 SMN1; SMN2 (0.44) IDO1TAAR1CHRM2CHRM1ALDH1A1
SCHEMBL10382788 0.86 ALDH1A1 (0.47) IDO1TAAR1CHRM2CHRM1HTT
SCHEMBL10382777 0.85 NPC1 (0.41) IDO1TAAR1CHRM2CHRM1HTT
SCHEMBL10383676 0.83 MEN1 (0.42) IDO1TAAR1CHRM2CHRM1L3MBTL1
SCHEMBL10382168 0.82 CXCR4 (0.41) IDO1TAAR1CHRM2CHRM1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0380463-A2 Method for preparing (R)-succinic acid derivatives MONSANTO COMPANY (US) 1990-08-01 EP claimed
US-4939288-A Catalytic hydrogenation MONSANTO COMPANY (US) 1990-07-03 US claimed
US-4515731-A Asymmetric catalysis MONSANTO COMPANY (US) 1985-05-07 US claimed
EP-0083332-A2 Asymmetric reduction of nitro-containing prochiral compounds MONSANTO COMPANY (US) 1983-07-06 EP claimed
US-4220590-A OPTICALLY ACTIVE BIS PHOSPHINE COMPOUNDS MONSANTO COMPANY (US) 1980-09-02 US claimed
US-4194051-A Asymmetric catalysis MONSANTO COMPANY (US) 1980-03-18 US claimed
US-4142992-A ASYMMETRIC CATALYSIS MONSANTO COMPANY (US) 1979-03-06 US claimed
US-4008281-A BIS-PHOSPHINE MONSANTO COMPANY (US) 1977-02-15 US claimed
EP-2537839-B1 B-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING B-DIHYDROFURAN DERIVING COMPOUND OR B-TETRAHYDROFURAN DERIVING COMPOUND, B -GLYCOSIDE COMPOUND, METHOD FOR PRODUCING B-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF NISSAN CHEMICAL IND LTD (JP) 2016-12-14 EP disclosed
US-9212174-B2 Certain β-dihydrofuran derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-12-15 US disclosed
EP-2537851-B1 PROCESS FOR PREPARATION OF B-GLYCOSIDE COMPOUNDS NISSAN CHEMICAL IND LTD (JP) 2015-06-10 EP disclosed
US-8975394-B2 Process for preparation of β-glycoside compounds NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-03-10 US disclosed
EP-2537851-A1 PROCESS FOR PREPARATION OF B-GLYCOSIDE COMPOUNDS Nissan Chemical Industries, Ltd. (JP) 2012-12-26 EP disclosed
EP-2537839-A1 B-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING B-DIHYDROFURAN DERIVING COMPOUND OR B-TETRAHYDROFURAN DERIVING COMPOUND, B -GLYCOSIDE COMPOUND, METHOD FOR PRODUCING B-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF Nissan Chemical Industries, Ltd. (JP) 2012-12-26 EP disclosed
EP-0040478-A1 Process for preparing pyridine derivatives and intermediates useful in the process IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-11-25 EP disclosed
US-4220590-A OPTICALLY ACTIVE BIS PHOSPHINE COMPOUNDS MONSANTO COMPANY (US) 1980-09-02 US disclosed
US-4204997-A Asymmetric amination of 1,3-dienes MONSANTO COMPANY (US) 1980-05-27 US disclosed
US-4194051-A Asymmetric catalysis MONSANTO COMPANY (US) 1980-03-18 US disclosed
US-4142992-A ASYMMETRIC CATALYSIS MONSANTO COMPANY (US) 1979-03-06 US disclosed
US-4008281-A BIS-PHOSPHINE MONSANTO COMPANY (US) 1977-02-15 US disclosed