Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17694561 | 0.82 | NOTUM (0.78) | TLR8NOTUMTSHRALDH1A1KDM4E | |
| SCHEMBL2610163 | 0.80 | NOTUM (0.75) | TLR8NOTUMTSHRALDH1A1KDM4E | |
| SCHEMBL4581181 | 0.79 | NOTUM (0.65) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL3088683 | 0.79 | TLR8 (0.64) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL28273399 | 0.78 | NOTUM (0.63) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL27967176 | 0.75 | TLR8 (0.58) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL27758236 | 0.75 | TLR8 (0.58) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL6386042 | 0.75 | TLR8 (0.73) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL6388915 | 0.75 | TLR8 (0.73) | TLR8NOTUMTSHRNPC1RAB9A | |
| SCHEMBL29376264 | 0.75 | TLR8 (0.58) | TLR8NOTUMTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152234-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2011-06-23 | — | — | US | disclosed |
| US-7956084-B2 | Phenyl thiophene carboxamide compounds as inhibitors of the enzyme IKK-2 | ASTRAZENECA AB (SE) | 2011-06-07 | — | — | US | disclosed |
| EP-2325189-A2 | Chemical coupling process with a phenyl boronic acid derivative | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| EP-2135873-A2 | Chemical coupling process with a phenyl boronic acid derivative | AstraZeneca AB (SE) | 2009-12-23 | — | — | EP | disclosed |
| US-20070015819-A1 | Novel compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2007-01-18 | — | — | US | disclosed |
| EP-1718655-A2 | CHEMICAL PROCESS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| US-7125896-B2 | Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| WO-2005080403-A2 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |
| US-20040242573-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
| EP-1421074-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003010158-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015819-A1 | Novel compounds | CNR1, ABCG2, CNR2 | TLR8 4311/4885NOTUM 2451/4885TSHR 182/4885 |
| US-20040242573-A1 | Novel compounds | SULT1E1, TPMT, UGT1A1 | TLR8 4520/4885NOTUM 3134/4885TSHR 529/4885 |
| US-20110152234-A1 | Novel Compounds | CNR1, ABCG2, CNR2 | TLR8 4311/4885NOTUM 2451/4885TSHR 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.