Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17694561 | 0.97 | NOTUM (0.78) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL5571187 | 0.91 | NOTUM (0.91) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| Biphenyl SCHEMBL22577775 | 0.88 | NOTUM (0.95) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL3537328 | 0.86 | NOTUM (1.00) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL860256 | 0.86 | NOTUM (0.64) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL19356867 | 0.86 | NOTUM (0.64) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL9096052 | 0.86 | NOTUM (0.64) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL14814390 | 0.86 | NOTUM (1.00) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL3685411 | 0.86 | NOTUM (0.64) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL368913 | 0.86 | NOTUM (0.64) | NOTUMKDM4EALDH1A1LMNATLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101109-A1 | ETHANOLAMINE SALT OF N- (3-METHOXY-5-METHYLPYRAZIN-2YL) -2- (4-[1, 3, 4-OXADIAZOLE-2-YL] PHENYL) PYRIDINE-3- SULPHONAMIDE | ASTRAZENECA AB (SE) | 2012-04-26 | — | — | US | disclosed |
| US-20120101109-A1 | ETHANOLAMINE SALT OF N- (3-METHOXY-5-METHYLPYRAZIN-2YL) -2- (4-[1, 3, 4-OXADIAZOLE-2-YL] PHENYL) PYRIDINE-3- SULPHONAMIDE | ASTRAZENECA AB (SE) | 2012-04-26 | — | — | US | disclosed |
| EP-1904490-B1 | ETHANOLAMINE SALT OF N- (3-METHOXY-5-METHYLPYRAZIN-2YL) -2- (4- [1 , 3 , 4-0XADIAZ0LE-2-YL]PHENYL) PYRIDINE-3- SULPHONAMIDE | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| US-20080221124-A1 | Ethanolamine Salt of N- (3-Methoxy-5-Methylpyrazin-2Yl) -2- (4-[1, 3, 4-Oxadiazole-2-Yl] Phenyl) Pyridine-3-Sulphonamide | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221124-A1 | Ethanolamine Salt of N- (3-Methoxy-5-Methylpyrazin-2Yl) -2- (4-[1, 3, 4-Oxadiazole-2-Yl] Phenyl) Pyridine-3-Sulphonamide | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| WO-2007010235-A1 | ETHANOLAMINE SALT OF N- (3-METHOXY-5-METHYLPYRAZIN-2YL) -2- (4- [1 , 3 , 4-0XADIAZ0LE-2-YL] PHENYL) PYRIDINE-3- SULPHONAMIDE | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101109-A1 | ETHANOLAMINE SALT OF N- (3-METHOXY-5-METHYLPYRAZIN-2YL) -2- (4-[1, 3, 4-OXADIAZOLE-2-YL] PHENYL) PYRIDINE-3- SULPHONAMIDE | SELENOI, PNMT, SLC6A3 | NOTUM 3353/4885KDM4E 1437/4885ALDH1A1 875/4885 |
| US-20080221124-A1 | Ethanolamine Salt of N- (3-Methoxy-5-Methylpyrazin-2Yl) -2- (4-[1, 3, 4-Oxadiazole-2-Yl] Phenyl) Pyridine-3-Sulphonamide | SELENOI, PNMT, NNMT | NOTUM 3361/4885KDM4E 708/4885ALDH1A1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.