Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14576359 | 0.87 | TLR8 (0.55) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL17694561 | 0.79 | NOTUM (0.78) | TLR8NOTUMLMNAHTTTSHR | |
| SCHEMBL12897340 | 0.79 | TLR8 (0.44) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL12897337 | 0.79 | TLR8 (0.44) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL4422718 | 0.78 | TLR8 (0.56) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL2610163 | 0.77 | NOTUM (0.75) | TLR8NOTUMLMNAHTTTSHR | |
| SCHEMBL6408072 | 0.77 | NOTUM (0.65) | TLR8NOTUMLMNAHTTHPGD | |
| SCHEMBL3088683 | 0.77 | TLR8 (0.64) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL4581181 | 0.77 | NOTUM (0.65) | TLR8NOTUMNPC1RAB9AL3MBTL1 | |
| SCHEMBL27967176 | 0.76 | TLR8 (0.58) | TLR8NOTUMNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| CN-111285850-B | Isoindoline compounds, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-04-22 | — | — | CN | disclosed |
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | TLR8 4095/4885NOTUM 1/4885NPC1 51/4885 |
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | CRBN, CUL4B, UBQLN1 | TLR8 2921/4885NOTUM 4254/4885NPC1 2554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.