Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 3/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL194797 | 0.90 | POLB (0.42) | POLBSMN1; SMN2TSHRALDH1A1MAPK1 | |
| Maleic Acid SCHEMBL2882692 | 0.90 | POLB (0.42) | POLBSMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL1845477 | 0.90 | ALDH1A1 (0.49) | TSHRALDH1A1MAPK1USP2CYP1A2 | |
| SCHEMBL1847339 | 0.86 | ALDH1A1 (0.48) | SMN1; SMN2TSHRALDH1A1MAPK1USP2 | |
| SCHEMBL1848688 | 0.86 | ALDH1A1 (0.37) | TSHRALDH1A1MAPK1USP2CYP1A2 | |
| SCHEMBL1848137 | 0.86 | KDM4E (0.51) | POLBTSHRALDH1A1MAPK1USP2 | |
| SCHEMBL1845608 | 0.85 | ALDH1A1 (0.38) | POLBSMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL1846364 | 0.83 | LMNA (0.42) | TSHRALDH1A1MAPK1USP2CYP1A2 | |
| SCHEMBL1845316 | 0.82 | POLB (0.39) | POLBSMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL1848808 | 0.82 | SMO (0.46) | POLBSMN1; SMN2ALDH1A1USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324023-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA (US) | 2011-05-25 | — | — | EP | claimed |
| WO-2009070164-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA (US) | 2009-06-04 | — | — | WO | claimed |
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2008-05-29 | — | — | US | claimed |
| US-5976523-A | PIPERIDINE- OR PIPERAZINE-SUBSTITUTED PYRROLOPYRIMIDINES | MITSUI PHARMACEUTICALS, INC. (JP) | 1999-11-02 | — | — | US | claimed |
| EP-0743066-A2 | Wound-healing agent | MITSUI PHARMACEUTICALS, INC. (JP) | 1996-11-20 | — | — | EP | claimed |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | Progenicyte Therapeutics, Inc. (US) | 2023-09-28 | — | — | US | disclosed |
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2021-02-18 | — | — | US | disclosed |
| US-20200246334-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2020-08-06 | — | — | US | disclosed |
| US-20190167674-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-20180092913-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2018-04-05 | — | — | US | disclosed |
| EP-2326330-B1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | UNIV CENTRAL FLORIDA RES FOUND (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8791128-B2 | Compositions for treating or delaying the onset of hair loss | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| WO-2010033576-A1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2009070164-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA (US) | 2009-06-04 | — | — | WO | disclosed |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TREMBLEY MARCELLA | 2009-04-02 | — | — | US | disclosed |
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2008-05-29 | — | — | US | disclosed |
| EP-1890673-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSMIP Assets B.V. (NL) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133876-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSM IP ASSETS B.V. (NL) | 2006-12-21 | — | — | WO | disclosed |
| US-5976523-A | PIPERIDINE- OR PIPERAZINE-SUBSTITUTED PYRROLOPYRIMIDINES | MITSUI PHARMACEUTICALS, INC. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0743066-A2 | Wound-healing agent | MITSUI PHARMACEUTICALS, INC. (JP) | 1996-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | TYMP, SLC18A3, SLC18A2 | POLB 943/4885SMN1; SMN2 205/4885TSHR 1811/4885 |
| US-20190167674-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | POLB 943/4885SMN1; SMN2 205/4885TSHR 1811/4885 |
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | PSEN1, PSEN2, NES | POLB 3126/4885SMN1; SMN2 80/4885TSHR 3594/4885 |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TYMP, TYMS, UNG | POLB 19/4885SMN1; SMN2 3270/4885TSHR 3157/4885 |
| US-20180092913-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | POLB 943/4885SMN1; SMN2 205/4885TSHR 1811/4885 |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | NES, PSEN1, PSEN2 | POLB 3750/4885SMN1; SMN2 78/4885TSHR 3492/4885 |
| US-20200246334-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | POLB 943/4885SMN1; SMN2 205/4885TSHR 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.