Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185444 | 0.79 | GCK (0.89) | GCKMAPT | |
| SCHEMBL185438 | 0.79 | GCK (0.65) | GCKTP53RXFP1LMNA | |
| SCHEMBL184750 | 0.78 | GCK (0.66) | GCKTP53RXFP1LMNA | |
| SCHEMBL185262 | 0.78 | GCK (0.64) | GCK | |
| SCHEMBL184948 | 0.76 | GCK (0.74) | GCKTP53POLBMAPTLMNA | |
| SCHEMBL184693 | 0.75 | GCK (0.64) | GCK | |
| SCHEMBL184398 | 0.75 | GCK (0.80) | GCKPOLB | |
| SCHEMBL184805 | 0.74 | GCK (0.77) | GCKMAPT | |
| SCHEMBL184721 | 0.73 | GCK (1.00) | GCK | |
| SCHEMBL184978 | 0.73 | PPARG (0.65) | GCKPOLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | claimed |
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |