Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | ACHE | P22303 | 2/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371597 | 0.91 | HDAC1 (0.73) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL14085827 | 0.84 | SMN1; SMN2 (0.81) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL14102524 | 0.82 | MAPT (0.80) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL10922779 | 0.81 | GSTO1 (0.74) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL10814398 | 0.81 | MEN1 (0.83) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL7372289 | 0.81 | HDAC1 (0.81) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL7371050 | 0.81 | HDAC1 (0.81) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL21484832 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL28199635 | 0.80 | RAB9A (0.72) | SMN1; SMN2RAB9ALMNAMAPTNPC1 | |
| SCHEMBL11137982 | 0.78 | MEN1 (0.70) | SMN1; SMN2RAB9ALMNAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017019772-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2017-02-02 | — | — | WO | disclosed |