Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18456576 | 0.83 | TGFBR1 (0.81) | TGFBR1TGFBR2 | |
| SCHEMBL18456948 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456608 | 0.79 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456558 | 0.76 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18425350 | 0.76 | TGFBR1 (0.69) | TGFBR1TGFBR2 | |
| SCHEMBL18456762 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL20436745 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456572 | 0.69 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456495 | 0.69 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456584 | 0.67 | TGFBR1 (1.00) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399987-B2 | TGF beta receptor antagonists | Bristol-Myer Squibb Company (US) | 2019-09-03 | — | — | US | claimed |
| US-10399987-B2 | TGF beta receptor antagonists | Bristol-Myer Squibb Company (US) | 2019-09-03 | — | — | US | disclosed |
| US-10399987-B2 | TGF beta receptor antagonists | Bristol-Myer Squibb Company (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180215762-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215762-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215762-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-02 | — | — | US | disclosed |
| WO-2017019757-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399987-B2 | TGF beta receptor antagonists | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885TGFBR2 2/4885 |
| US-20180215762-A1 | TGF BETA RECEPTOR ANTAGONISTS | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885TGFBR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.