Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18425966 | 0.90 | SCD (0.78) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18456883 | 0.88 | LRRK2 (0.67) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18456886 | 0.78 | HSD17B1 (0.62) | SCDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16554294 | 0.77 | SCD (1.00) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL31024 | 0.76 | HSD17B1 (0.82) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21753691 | 0.76 | LRRK2 (1.00) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL31055 | 0.76 | SCD (0.84) | SCDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21753712 | 0.74 | LRRK2 (1.00) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21753706 | 0.74 | LRRK2 (1.00) | SCDLRRK2ALDH1A1MEN1KMT2A | |
| SCHEMBL16554035 | 0.73 | HSD17B1 (0.76) | SCDLRRK2ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017019772-A1 | MODULATORS OF MYOCYTE LIPID ACCUMULATION AND INSULIN RESISTANCE AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2017-02-02 | — | — | WO | disclosed |