Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.66 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843205 | 0.93 | MAPT (0.82) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1846139 | 0.91 | HTR6 (0.67) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1846585 | 0.91 | MAPT (0.71) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1844791 | 0.91 | MAPT (0.81) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1844591 | 0.91 | MAPT (0.73) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1845809 | 0.90 | DCTPP1 (0.81) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL20640023 | 0.89 | MAPT (0.79) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2389209 | 0.88 | MAPT (0.70) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1842031 | 0.88 | DCTPP1 (0.78) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL1843801 | 0.88 | MAPT (0.70) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320897-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | Treventis Corporation (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | claimed |
| US-11568956-B2 | Methods for identifying inhibitors of amyloid protein aggregation | TREVENTIS CORPORATION (US) | 2023-01-31 | — | — | US | disclosed |
| US-20190050526-A1 | METHODS FOR IDENTIFYING INHIBITORS OF AMYLOID PROTEIN AGGREGATION | TREVENTIS CORPORATION (US) | 2019-02-14 | — | — | US | disclosed |
| US-20160283652-A1 | METHODS FOR IDENTIFYING INHIBITORS OF AMYLOID PROTEIN AGGREGATION | TREVENTIS CORPORATION (US) | 2016-09-29 | — | — | US | disclosed |
| CN-102170882-B | Compositions and methods of treating amyloid disease | TREVENTIS CORP | 2014-04-02 | — | — | CN | disclosed |
| US-8420640-B2 | Methods of treating amyloid disease using analogs of 1-(4-nitrophenyl) piperazine | TREVENTIS CORPORATION (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110218200-A1 | METHODS OF TREATING AMYLOID DISEASE USING ANALOGS OF 1-(4-NITROPHENYL) PIPERAZINE | TREVENTIS CORPORATION | 2011-09-08 | — | — | US | disclosed |
| EP-2320897-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | Treventis Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218200-A1 | METHODS OF TREATING AMYLOID DISEASE USING ANALOGS OF 1-(4-NITROPHENYL) PIPERAZINE | PSEN1, PSEN2, APP | MAPT 10/4885ALDH1A1 1948/4885NPSR1 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.