Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18474049 | 0.86 | MEN1 (0.37) | SLC22A1CYP3A4CYP2D6TSHRGRIN1 | |
| SCHEMBL12646217 | 0.85 | OPRM1 (0.36) | SLC22A1CYP3A4CYP2D6TSHRGRIN1 | |
| SCHEMBL12013639 | 0.85 | OPRM1 (0.36) | SLC22A1CYP3A4CYP2D6TSHRGRIN1 | |
| SCHEMBL18458091 | 0.85 | OPRM1 (0.36) | SLC22A1CYP3A4CYP2D6TSHRGRIN1 | |
| SCHEMBL22058857 | 0.83 | OPRM1 (0.37) | SLC22A1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL2150392 | 0.82 | GAA (0.48) | GAASLC22A1CYP3A4CYP2D6TSHR | |
| SCHEMBL14768978 | 0.81 | GAA (0.66) | GAASLC22A1CYP3A4CYP2D6TSHR | |
| SCHEMBL10222582 | 0.81 | GAA (0.66) | GAASLC22A1CYP3A4CYP2D6TSHR | |
| SCHEMBL16553121 | 0.77 | GAA (0.37) | GAASLC22A1OPRM1OPRD1OPRK1 | |
| SCHEMBL12588838 | 0.76 | PTGER4 (0.33) | SLC22A1CYP3A4CYP2D6TSHRGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029432-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT ENTERPRISES LLC | 2017-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029432-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | TLR9, TLR3, TLR7 | GAA 1100/4885SLC22A1 1664/4885CYP3A4 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.