Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101168 | 0.80 | ALDH1A1 (0.53) | MAPTPTGS2AKR1C3AKR1C2TDP1 | |
| SCHEMBL28211107 | 0.79 | ERN1 (0.36) | ERN1EIF4EGRIA4MAPTPTPRC | |
| SCHEMBL18458703 | 0.78 | ERN1 (0.34) | ERN1EIF4EGRIA4PTGS2IDH2 | |
| SCHEMBL18458704 | 0.76 | IDH2 (0.54) | IDH2CNR1POLBALDH1A1 | |
| SCHEMBL18458412 | 0.76 | IDH2 (0.54) | PTGS2IDH2KMT2AALDH1A1 | |
| SCHEMBL15741263 | 0.76 | S100A4 (0.47) | ERN1EIF4EMAPTPTPRCCYP2A6 | |
| SCHEMBL18458311 | 0.74 | MAPT (0.48) | ERN1EIF4EMAPTAKR1C3AKR1C2 | |
| SCHEMBL28211109 | 0.74 | ERN1 (0.35) | ERN1EIF4EMAPTAKR1C3AKR1C2 | |
| SCHEMBL5913505 | 0.73 | ERN1 (0.52) | ERN1EIF4EMAPTMEN1KMT2A | |
| SCHEMBL5913395 | 0.73 | ERN1 (0.40) | ERN1EIF4EMAPTPTPRCMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330263-B1 | PHENYLUREA DERIVATIVES AS ISOCITRATE DEHYDROGENASE 2 INHIBITORS FOR TREATING CANCER | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2020-11-18 | — | — | EP | disclosed |
| CN-107922375-B | Anti-tumor compounds targeting the IDH2 mutation and methods of use thereof | 正大天晴药业集团股份有限公司 | 2020-05-22 | — | — | CN | disclosed |
| US-10155722-B2 | Antitumor compound targeting IDH2 mutation and method of use thereof | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-12-18 | — | — | US | disclosed |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-3330263-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2018-06-06 | — | — | EP | disclosed |
| WO-2017016523-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | 正大天晴药业集团股份有限公司 | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155722-B2 | Antitumor compound targeting IDH2 mutation and method of use thereof | IDH2, IDH3A, IDH1 | ERN1 3582/4885EIF4E 3150/4885GRIA4 2287/4885 |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | IDH2, IDH3A, IDH1 | ERN1 3582/4885EIF4E 3150/4885GRIA4 2287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.