Amifostine

Amifostine

SCHEMBL18464

NCCCNCCSP(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 2/20 1.00
DRD3 P35462 1/20 1.00
CA12 O43570 3/20 0.46
CA2 P00918 3/20 0.46
CA4 P22748 3/20 0.46
CA6 P23280 3/20 0.46
CA5A P35218 3/20 0.46
CA7 P43166 3/20 0.46
CA9 Q16790 3/20 0.46
CA14 Q9ULX7 3/20 0.46
CA5B Q9Y2D0 3/20 0.46
CASP2 P42575 2/20 0.46
F13A1 P00488 2/20 0.46
CYP1A2 P05177 2/20 0.46
ALOX15 P16050 2/20 0.46
THPO P40225 2/20 0.46
MEN1 O00255 1/20 0.46
CYP2C19 P33261 1/20 0.46
RECQL P46063 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amifostine SCHEMBL4709602 1.00 BLM (1.00) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL5309668 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL4562808 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL317195 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL1231172 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL4732534 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL4383022 0.98 BLM (0.96) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL20213780 0.96 BLM (0.93) BLMDRD3CA12CA2CA4
Amifostine SCHEMBL9614263 0.94 DRD3 (0.89) BLMDRD3CA12CA2CA4
SCHEMBL789954 0.94 DRD3 (0.89) BLMDRD3CA12CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 37353 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
CN-122056884-A Methods of treating pancreatic cancer 坎莫森特里克斯公司 2026-05-19 CN claimed
CN-120899899-B Gamma delta T cell preparation and preparation method and application thereof 广州淳泰生物医药科技有限公司 2026-05-15 CN claimed
WO-2026102332-A1 NERVE AND TUMOR HOMING AGENTS AND METHODS OF USE THEREOF Blaze Bioscience, Inc. (US) 2026-05-15 WO claimed
EP-3978473-B1 COMPOUND CONTAINING AN INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF BEIJING AN JIAN XI BIO MEDICAL TECH CO LTD (CN) 2026-05-06 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260108476-A1 2,4 DNP and Prodrugs Thereof for Treatment of Cancer MITOCHON PHARMACEUTICALS, INC. (US) 2026-04-23 US claimed
EP-4729063-A2 TREATMENT OF CANCER USING COENZYME Q10 COMBINATION THERAPIES BPGbio, Inc. (US) 2026-04-22 EP claimed
US-12582672-B2 Vanadium compositions and methods for treatment of cancer THE BROAD INSTITUTE, INC. (US) 2026-03-24 US claimed
EP-4709378-A1 COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2026-03-18 EP claimed
WO-1994003179-A1 CRYSTALLINE AMIFOSTINE COMPOSITIONS AND METHODS FOR THE PREPARATION AND USE OF SAME U.S. BIOSCIENCE, INC. (US) 1994-02-17 WO claimed
EP-0359347-B1 COVALENTLY-LINKED COMPLEXES AND METHODS FOR ENHANCED CYTOTOXICITY AND IMAGING NEORX CORPORATION (US) 1992-12-23 EP claimed
US-5167947-A Enhancement of absorption of radioprotective drugs SOUTHWEST RESEARCH INSTITUTE (US) 1992-12-01 US claimed
EP-0473673-A1 METHOD FOR PROTECTION FROM AZT SIDE EFFECTS AND TOXICITY U.S. BIOSCIENCE (US) 1992-03-11 EP claimed
EP-0409845-A4 METHOD FOR PROTECTION FROM CHEMOTHERAPEUTIC SIDE EFFECTS 1991-07-03 EP claimed
EP-0409845-A1 METHOD FOR PROTECTION FROM CHEMOTHERAPEUTIC SIDE EFFECTS U.S. BIOSCIENCE (US) 1991-01-30 EP claimed
WO-1990014007-A1 METHOD FOR PROTECTION FROM AZT SIDE EFFECTS AND TOXICITY U.S. BIOSCIENCE (US) 1990-11-29 WO claimed
EP-0359347-A2 Covalently-linked complexes and methods for enhanced cytotoxicity and imaging NEORX CORPORATION (US) 1990-03-21 EP claimed
US-4889525-A WITH AQUEOUS DISPERSION OF OXYGEN CARRYING PERFLUORO COMPOUND AND DISPERSANT ADAMANTECH, INC. (US) 1989-12-26 US claimed
WO-1989007942-A1 METHOD FOR PROTECTION FROM CHEMOTHERAPEUTIC SIDE EFFECTS U.S. BIOSCIENCE (US) 1989-09-08 WO claimed