Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.96 |
| ▸ | DRD3 | P35462 | 1/20 | 0.96 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA4 | P22748 | 3/20 | 0.44 |
| ▸ | CA6 | P23280 | 3/20 | 0.44 |
| ▸ | CA5A | P35218 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.44 |
| ▸ | CASP2 | P42575 | 2/20 | 0.44 |
| ▸ | F13A1 | P00488 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | THPO | P40225 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amifostine SCHEMBL18464 | 0.98 | BLM (1.00) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL4709602 | 0.98 | BLM (1.00) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL5309668 | 0.96 | BLM (0.96) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL4562808 | 0.96 | BLM (0.96) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL317195 | 0.96 | BLM (0.96) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL4732534 | 0.96 | BLM (0.96) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL1231172 | 0.96 | BLM (0.96) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL20213780 | 0.94 | BLM (0.93) | BLMDRD3CA12CA2CA4 | |
| Amifostine SCHEMBL9614263 | 0.93 | DRD3 (0.89) | BLMDRD3CA12CA2CA4 | |
| SCHEMBL789954 | 0.92 | DRD3 (0.89) | BLMDRD3CA12CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629333-B2 | Stable amorphous amifostine compositions and methods for the preparation and use of same | MEDIMMUNE, LLC (US) | 2009-12-08 | — | — | US | disclosed |
| US-20050209200-A1 | Stable amorphous amifostine compositions and methods for the preparation and use of same | MEDIMMUNE ONCOLOGY, INC. | 2005-09-22 | — | — | US | disclosed |
| US-6841545-B2 | Stable amorphous amifostine compositions and methods for the preparation of same | MEDIMMUNE ONCOLOGY, INC. (US) | 2005-01-11 | — | — | US | disclosed |
| US-20020147180-A1 | Stable amorphous amifostine compositions and methods for the preparation of same | MEDIMMUNE ONCOLOGY, INC. | 2002-10-10 | — | — | US | disclosed |
| US-6407278-B2 | HEAT RESISTANCE DOSAGE FORMS | MEDIMMUNE ONCOLOGY, INC. | 2002-06-18 | — | — | US | disclosed |
| US-6384259-B1 | HEAT RESISTANT, STERILE DOSAGE SUITABLE FOR RECONSTITUTION WITH A VEHICLE INTO AN INJECTIBLE, PARTICLE-FREE PRODUCT FOR PARENTERAL ADMINISTRATION | MEDIMMUNE ONCOLOGY, INC. | 2002-05-07 | — | — | US | disclosed |
| US-20020010357-A1 | STABLE AMORPHOUS AMIFOSTINE COMPOSITIONS AND DOSAGE FORM | CLINIGEN GROUP PLC (GB) | 2002-01-24 | — | — | US | disclosed |
| EP-1131103-A1 | STABLE AMORPHOUS AMIFOSTINE COMPOSITIONS AND METHODS FOR THE PREPARATION AND USE OF SAME | U.S. BIOSCIENCE, INC. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029025-A1 | STABLE AMORPHOUS AMIFOSTINE COMPOSITIONS AND METHODS FOR THE PREPARATION AND USE OF SAME | U.S. BIOSCIENCE, INC. (US) | 2000-05-25 | — | — | WO | disclosed |