SCHEMBL18464241

SCHEMBL18464241

COC(=O)[C@H](CCCNC(=N)N)NC(=O)C(C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 9/20 0.42
▸ NPY1R P25929 5/20 0.42
▸ FOLH1 Q04609 1/20 0.36
▸ PDF Q9HBH1 1/20 0.35
▸ GRIA1 P42261 1/20 0.34
▸ NPY2R P49146 3/20 0.34
▸ NPY5R Q15761 3/20 0.34
▸ TSHR P16473 1/20 0.33
▸ ERAP1 Q9NZ08 1/20 0.33
▸ LNPEP Q9UIQ6 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ TGM2 P21980 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4552682 0.86 FOLH1 (0.40) NPY4RNPY1RFOLH1GRIA1NPY2R
SCHEMBL1724846 0.86 FOLH1 (0.40) NPY4RNPY1RFOLH1GRIA1NPY2R
SCHEMBL5807981 0.84 NPY4R (0.44) NPY4RNPY1RFOLH1PDFNPY2R
SCHEMBL2390736 0.84 NPY4R (0.44) NPY4RNPY1RFOLH1PDFNPY2R
SCHEMBL21879809 0.84 NPY4R (0.44) NPY4RNPY1RFOLH1PDFNPY2R
SCHEMBL28672685 0.84 MEN1 (0.47) NPY4RNPY1RMEN1GAAKMT2A
SCHEMBL21284538 0.84 GRIA1 (0.33) NPY4RNPY1RPDFGRIA1ERAP1
SCHEMBL5849013 0.84 MEN1 (0.47) NPY4RNPY1RMEN1GAAKMT2A
Hydrochloric Acid SCHEMBL11506342 0.83 NPY4R (0.44) NPY4RNPY1RFOLH1PDFNPY2R
Hydrochloric Acid SCHEMBL10870558 0.83 MEN1 (0.46) NPY4RNPY1RMEN1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4363433-B1 PEPTIDE SYNTHESIS METHOD INVOLVING STERICALLY HINDERED MIXED ANHYDRIDE INTERMEDIATE AMICOAT AS (NO) 2025-10-08 — — EP disclosed
US-20240174713-A1 PEPTIDE SYNTHESIS METHOD INVOLVING STERICALLY HINDERED MIXED ANHYDRIDE INTERMEDIATE PHARMA HOLDINGS AS (NO) 2024-05-30 — — US disclosed
WO-2023275410-A1 PEPTIDE SYNTHESIS METHOD INVOLVING STERICALLY HINDERED MIXED ANHYDRIDE INTERMEDIATE AMICOAT AS (NO) 2023-01-05 — — WO disclosed
US-10961202-B2 Bis-benzimidazole compounds and methods of using the same THE SCRIPPS RESEARCH INSTITUTE (US) 2021-03-30 — — US disclosed
US-20190152924-A1 BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2019-05-23 — — US disclosed
US-20170029381-A1 TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 JANSSEN PHARMACEUTICA NV (BE) 2017-02-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10961202-B2 Bis-benzimidazole compounds and methods of using the same HNRNPH1, HNRNPH3, HNRNPUL2 NPY4R 4703/4885NPY1R 4789/4885FOLH1 726/4885
US-20240174713-A1 PEPTIDE SYNTHESIS METHOD INVOLVING STERICALLY HINDERED MIXED ANHYDRIDE INTERMEDIATE VIP, GRPR, SSTR4 NPY4R 42/4885NPY1R 41/4885FOLH1 145/4885
US-20190152924-A1 BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING THE SAME HNRNPH1, HNRNPH3, HNRNPUL2 NPY4R 4703/4885NPY1R 4789/4885FOLH1 726/4885
US-20170029381-A1 TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 GLRA1, GRM5, TRHR NPY4R 34/4885NPY1R 21/4885FOLH1 3719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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