Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30553151 | 0.85 | ALOX15 (0.44) | MEN1KMT2ASMN1; SMN2ALOX15CYP3A4 | |
| SCHEMBL4385711 | 0.81 | TYR (0.59) | MEN1KMT2AALOX15CYP3A4HTT | |
| SCHEMBL2437476 | 0.81 | ALOX15 (0.44) | MEN1KMT2ASMN1; SMN2ALOX15CYP3A4 | |
| SCHEMBL11317550 | 0.80 | CNR1 (0.48) | MEN1KMT2AALOX15HTTHPGD | |
| SCHEMBL1837486 | 0.80 | ESR1 (0.50) | ESR1ESR2AR | |
| SCHEMBL3804565 | 0.79 | NR3C1 (0.41) | ALOX15HTTLMNAHSP90AA1HSD17B10 | |
| SCHEMBL2776987 | 0.78 | ALOX15 (0.50) | SMN1; SMN2ALOX15CYP3A4HPGDLMNA | |
| SCHEMBL22898323 | 0.78 | TDP1 (0.50) | MEN1KMT2ASMN1; SMN2CYP3A4HTT | |
| SCHEMBL19068311 | 0.77 | HTT (0.38) | MEN1KMT2ASMN1; SMN2CYP3A4HTT | |
| SCHEMBL11317922 | 0.77 | HSD17B10 (0.50) | MEN1KMT2ASMN1; SMN2ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | ARAXES PHARMA LLC (US) | 2021-02-16 | — | — | US | disclosed |
| US-9562002-B2 | STAT3 inhibitor | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919850-B2 | Covalent inhibitors of KRas G12C | KRAS, NRAS, HRAS | MEN1 2271/4885KMT2A 535/4885SMN1; SMN2 3761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.