Sugi Predict

Sugi Predict / Compounds / SCHEMBL1847263

SCHEMBL1847263

SCHEMBL1847263

CCOc1ccc(Br)cc1Br

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.58
▸ MAPK1 P28482 3/20 0.58
▸ TDP1 Q9NUW8 2/20 0.58
▸ L3MBTL1 Q9Y468 2/20 0.58
▸ HPGD P15428 4/20 0.54
▸ TSHR P16473 3/20 0.54
▸ MAPT P10636 3/20 0.53
▸ SMN1; SMN2 Q16637 5/20 0.47
▸ LMNA P02545 5/20 0.47
▸ RAB9A P51151 4/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ NPC1 O15118 3/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ HTT P42858 1/20 0.46
▸ ATM Q13315 1/20 0.46
▸ GAA P10253 1/20 0.45
▸ HTR1B P28222 1/20 0.44
▸ PKM P14618 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL182753 0.84 TSHR (0.56) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL31096231 0.84 TSHR (0.56) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL27082290 0.83 ALDH1A1 (0.48) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL20764690 0.83 HPGD (0.50) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL10801072 0.82 TDP1 (0.62) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL27973236 0.82 TDP1 (0.52) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL4697408 0.81 L3MBTL1 (0.75) ALDH1A1MAPK1TDP1L3MBTL1HPGD
SCHEMBL30753685 0.81 NQO1 (0.52) ALDH1A1TDP1L3MBTL1HPGDTSHR
SCHEMBL257828 0.81 HPGD (0.53) ALDH1A1MAPK1TDP1HPGDTSHR
SCHEMBL28232913 0.81 NQO1 (0.52) ALDH1A1TDP1L3MBTL1HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12071418-B2 Processes for preparation of dapagliflozin or its solvates or co-crystals thereof LAURUS LABS LIMITED (IN) 2024-08-27 — — US disclosed
US-20220372010-A1 PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2022-11-24 — — US disclosed
US-11427555-B2 Processes for preparation of dapagliflozin or its solvates or co-crystals thereof LAURUS LABS LIMITED (IN) 2022-08-30 — — US disclosed
EP-3497090-B1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LTD (IN) 2022-08-03 — — EP disclosed
US-20210323939-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2021-10-21 — — US disclosed
EP-3497090-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF Laurus Labs Limited (IN) 2019-06-19 — — EP disclosed
WO-2018029611-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2018-02-15 — — WO disclosed
WO-2018029611-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2018-02-15 — — WO disclosed
US-20110155950-A1 PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES BASF SE (DE) 2011-06-30 — — US disclosed
EP-2323966-A1 PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES BASF SE (DE) 2011-05-25 — — EP disclosed
WO-2010015559-A1 PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES BASF SE (DE) 2010-02-11 — — WO disclosed
EP-0988262-A1 BROMINATION PROCESS ALBEMARLE CORPORATION (US) 2000-03-29 — — EP disclosed
EP-0761633-B1 Process for the preparation of (4-bromophenyl) alkyl ethers CLARIANT GMBH (DE) 1999-12-15 — — EP disclosed
WO-1998056737-A1 BROMINATION PROCESS ALBEMARLE CORPORATION (US) 1998-12-17 — — WO disclosed
US-5817888-A Bromination process ALBEMARLE CORPORATION (US) 1998-10-06 — — US disclosed
US-5654493-A Process for preparing 4-bromophenyl alkyl ethers HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-05 — — US disclosed
EP-0761633-A2 Process for the preparation of 4-bromophenyl alkyl ethers HOECHST AKTIENGESELLSCHAFT (DE) 1997-03-12 — — EP disclosed
WO-1992013820-A1 PROCESS FOR THE PREPARATION OF ALKYL-4-HALOPHENYL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-08-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220372010-A1 PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF SLC5A1, SLC5A2, DPP4 ALDH1A1 1691/4885MAPK1 597/4885TDP1 2884/4885
US-11427555-B2 Processes for preparation of dapagliflozin or its solvates or co-crystals thereof SLC5A1, SLC5A2, DPP4 ALDH1A1 2084/4885MAPK1 595/4885TDP1 3317/4885
US-20210323939-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF SLC5A1, SLC5A2, DPP4 ALDH1A1 1945/4885MAPK1 666/4885TDP1 3205/4885
US-12071418-B2 Processes for preparation of dapagliflozin or its solvates or co-crystals thereof SLC5A1, SLC5A2, SLC2A4 ALDH1A1 1889/4885MAPK1 591/4885TDP1 2145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.