Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.39 |
| ▸ | VNN1 | O95497 | 4/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | BTD | P43251 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856639 | 0.88 | VNN1 (0.37) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL2787463 | 0.83 | VNN1 (0.38) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL185596 | 0.83 | VNN1 (0.38) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL14856868 | 0.80 | HDAC1 (0.45) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL184726 | 0.79 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL2812645 | 0.79 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL198148 | 0.77 | CYP4F2 (0.32) | — | |
| SCHEMBL14856657 | 0.76 | KDM4E (0.45) | DGAT2 | |
| SCHEMBL185855 | 0.75 | KDM4E (0.41) | DGAT2 | |
| SCHEMBL14856727 | 0.74 | CYP4F2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |