Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2755849 | 0.86 | CA12 (0.57) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL30499689 | 0.86 | CA12 (0.57) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL20560615 | 0.86 | EPHX2 (0.56) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL12144664 | 0.86 | EPHX2 (0.57) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL1008398 | 0.85 | POLB (0.63) | MEN1KMT2APOLBKDM4EGAA | |
| SCHEMBL11067319 | 0.84 | TAS2R14 (0.63) | EPHX2TAS2R14MEN1KMT2APOLB | |
| SCHEMBL5917671 | 0.82 | GPR35 (0.49) | EPHX2TAS2R14MEN1KMT2APOLB | |
| SCHEMBL12780371 | 0.82 | EPHX2 (0.58) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL881580 | 0.82 | CA12 (0.53) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL4003395 | 0.82 | EPHX2 (0.56) | EPHX2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324029-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010030785-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS INC. (US) | 2010-03-18 | — | — | WO | disclosed |