Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616555 | 0.84 | SLC6A2 (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL30743773 | 0.84 | SLC6A2 (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL15896884 | 0.84 | SLC6A2 (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL19827913 | 0.81 | HTR2C (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL19835604 | 0.81 | HTR2C (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL18643709 | 0.81 | HTR2C (0.37) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL17193929 | 0.78 | HTR2C (0.45) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL18372009 | 0.78 | GAA (0.36) | ACHECHRNB2CHRNA4HTR2CSLC6A2 | |
| SCHEMBL31394451 | 0.78 | HTR2A (0.45) | HTR2CCA1CA2HTR2BHTR2A | |
| SCHEMBL19828061 | 0.78 | ACHE (0.34) | ACHECHRNB2CHRNA4HTR2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287053-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | ALCHEMEDICINE, INC. (JP) | 2024-08-29 | — | — | US | disclosed |
| EP-4361146-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | Alchemedicine, Inc. (JP) | 2024-05-01 | — | — | EP | disclosed |
| CN-117255791-A | Compounds, endothelin A receptor antagonists and pharmaceutical compositions | 亚克医药株式会社 | 2023-12-19 | — | — | CN | disclosed |
| WO-2022270487-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | 株式会社アークメディスン | 2022-12-29 | — | — | WO | disclosed |
| EP-3133071-A1 | C-ARYL INDICAN DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai De Novo Pharmatech Co Ltd. (CN) | 2017-02-22 | — | — | EP | disclosed |
| US-20170037038-A1 | C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF | SHANGHAI DE NOVO PHARMATECH CO. LTD. (CN) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287053-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | EDNRA, EDNRB, ECE1 | ACHE 1551/4885CHRNB2 514/4885CHRNA4 520/4885 |
| US-20170037038-A1 | C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF | SLC5A2, SLC5A1, MGAT1 | ACHE 3471/4885CHRNB2 2471/4885CHRNA4 3508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.