Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17360612 | 0.87 | SRD5A1 (0.41) | SRD5A1SRD5A2TLR9TLR7HPGD | |
| SCHEMBL3912610 | 0.87 | TRPV3 (0.41) | SRD5A1SRD5A2TLR9TLR7NPC1 | |
| SCHEMBL15984664 | 0.86 | ELANE (0.42) | SRD5A1SRD5A2TLR9TLR7 | |
| SCHEMBL7163724 | 0.83 | SRD5A1 (0.51) | SRD5A1SRD5A2HPGDNPC1RAB9A | |
| SCHEMBL29264495 | 0.81 | SRD5A1 (0.49) | SRD5A1SRD5A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29821188 | 0.81 | SRD5A2 (0.47) | SRD5A2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1179548 | 0.81 | SRD5A2 (0.53) | SRD5A2HPGDNPC1RAB9AHDAC1 | |
| SCHEMBL3898829 | 0.81 | SRD5A2 (0.47) | SRD5A2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17417658 | 0.80 | SRD5A1 (0.50) | SRD5A1SRD5A2TLR9TLR7HPGD | |
| SCHEMBL1777494 | 0.80 | TLR9 (0.49) | SRD5A1SRD5A2TLR9TLR7HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |