Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984664 | 0.91 | ELANE (0.42) | SRD5A1SRD5A2TLR9TLR7PTGER1 | |
| SCHEMBL18474166 | 0.87 | SRD5A1 (0.55) | SRD5A1SRD5A2TLR9TLR7NPC1 | |
| SCHEMBL17360345 | 0.87 | SRD5A2 (0.46) | SRD5A1SRD5A2BRD4NPC1HPGD | |
| SCHEMBL3912610 | 0.85 | TRPV3 (0.41) | SRD5A1SRD5A2TLR9TLR7PTGER1 | |
| SCHEMBL3898829 | 0.79 | SRD5A2 (0.47) | SRD5A2NPC1RAB9AYAP1 | |
| SCHEMBL29821188 | 0.79 | SRD5A2 (0.47) | SRD5A2NPC1RAB9AYAP1 | |
| SCHEMBL1179548 | 0.79 | SRD5A2 (0.53) | SRD5A2CYP2C9NPC1HPGDRAB9A | |
| SCHEMBL3899755 | 0.76 | NR1H2 (0.47) | SRD5A2NR1H2NR1H3PRMT5PIK3CD | |
| SCHEMBL17360243 | 0.75 | ELANE (0.47) | SRD5A1SRD5A2PTGER1BRD4NPC1 | |
| SCHEMBL29264495 | 0.75 | SRD5A1 (0.49) | SRD5A1SRD5A2PTGER1BRD4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960238-B1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2960238-B1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2960238-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |
| EP-2960238-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |